Purpose: Was to provide a solution to the problem of persistent silicone oil induced glaucoma (SOIG), which represents a common type of intractable glaucoma that usually adds to the hazards of complicated vitreoretinal surgeries. The trial aimed to evaluate the efficacy and safety of an augmented adjunctive approach of various lines combined with surgical glaucoma treatment. Patients and Methods: Twenty-four eyes of 24 patients presented with SOIG were included in this interventional case series clinical trial. All eyes underwent trabeculectomy with intraoperative mitomycin-C (MMC) application plus bevacizumab injection (1.25 mg) together with early postoperative topical MMC drops (0.03 mg/ml). The main outcome results included the cumulative probability of surgical success, intraocular pressure (IOP) values, number of anti-glaucoma drugs needed, corrected distance visual acuity, any reported complication or additional intervention. Results: This combined approach achieved a cumulative probability of success of 0.765 at the end of the 24 months study period and was in a range of 0.883 at 2 weeks and 0.647 at 6 months. Complete success was achieved in a range of 82.4% at 2 weeks and 35.3% at 18 and 24 months. There were always highly statistically significant decreases in the mean IOP values and numbers of the given IOP-lowering drugs at all postoperative time points (P was always <0.001). All complications were controlled with no major drawbacks. No significant adverse effects were caused by this combined approach. Conclusion: The combined approach could present an efficient, safe, familiar, and applicable treatment strategy for the treatment of persistent SOIG. It can provide a favorable long-term outcome representing a simple solution to the problem of persistent SOIG, which represents a challenging type of refractory glaucoma.

Context: Pregnancy induced hypertension (PIH) is defined as hypertensive disorder of pregnancy, which occurs in the absence of other causes of elevated blood pressure (BP) and is associated with pedal edema, proteinuria or both. Aims: To evaluate the ocular fundus changes and its relation with the severity of proteinuria and BP in PIH patients. Settings and Design: Hospital based prospective observational study. Subjects and Methods: Study conducted over a period of 2 years. A total 100 patients of pregnancy having preeclampsia and eclampsia were included. Statistical Analysis Used: Chi-square test. Results: Of 100 cases 32 (32%) had mild preeclampsia while 50 (50%) had severe preeclampsia. Eighteen (18%) patients had eclampsia. All cases had proteinuria of varying degree ranging from 1+ to 4+. Forty-four cases (44%) had retinal changes. Cases with severe proteinuria and higher BP had more severe grades of retinopathy. Conclusions: Examination of fundus by ophthalmoscope is simple, noninvasive, safe, and reliable procedure, which can be done in out-patient department or at bedside. It should be done routinely in all patients of PIH. It is the BP, systolic and diastolic to which the severity of the retinal changes was found to be directly proportional. Higher grades of proteinuria were associated with higher grades of retinal changes.

Introduction: The objective of this study is to provide baseline optical coherence tomography (OCT) macular parameters data in Indian subjects with cataract and to compare these parameters with the published normative data on Indian population to understand the effect of cataract on macular thickness using cirrus spectral domain OCT. Material and Methods: This was a prospective, observational, cross-sectional analysis of 108 eyes of 108 cataract cases of north Indian origin. Results: It was observed that age of the patients and the best corrected visual acuity (BCVA) are not found to be the independent factor predicting the change in the mean values of different OCT parameters of macular thickness studied (linear regression analysis β = −2.197 to 0.34, P = 0.902–0.073). Comparison of mean values of different OCT parameters of macular thickness of studied patients with the normative population data from Indian population showed statistical difference in the values with noncataractous population having higher values for most of the studied parameters (t-test; t = 93.6–9.2, P = 0.007–0.043). Conclusion: Though the mean macular thickness of a cataract patient is lesser than that of population, age of the cataract patient does not independently predict the variation in baseline macular thickness. The BCVA achieved after an uneventful cataract surgery is found to be independent of baseline macular thickness of the patient. Moreover the presence of cataract or its grade is not associated with baseline macular thickness of the patient.

Vogt–Koyanagi–Harada syndrome is an inflammatory multisystem disorder with ocular, cutaneous and neurological manifestations occurring more commonly in certain dark-skinned ethnic groups such as Asians, patients of Middle-Eastern heritage, and hispanics. Only a few reports have described a masquerade presentation of acute angle closure as an initial manifestation for this uveitic entity, which is typically characterized by panuveitis with serous retinal detachments. This has almost always led to misdiagnosis, unwarranted surgical interventions, and a delay of appropriate timely therapy. In this report, we describe an unusual case of acute unilateral Harada disease presenting as acute angle-closure glaucoma that has remitted following institution of appropriate therapy.

We report a case of a 28-year-old man who developed central serous retinopathy 2 days after he sustained a contused lacerated wound over the right eyebrow in a road traffic accident.

Bear track dystrophy, is a rare condition, which forms part of the disorder known as the grouped congenital hypertrophy of the retinal pigment epithelium (CHRPE), a peculiar congenital anomaly of the retinal pigment epithelium diagnosed by its characteristic ophthalmoscopic appearance. This disorder is usually without any functional consequence with patients typically having a normal vision, color vision, normal visual fields, dark adaptation, electroretinography, and electrooculography findings. The main differential diagnosis of CHRPE includes choroidal naevus, choroidal melanoma, chorioretinal scar, subretinal hematoma, pigmented epiretinal membrane, and reactive retinal pigment epithelial hyperplasia. Since CHRPE, in itself is a totally benign condition with no associated ocular or systemic complications, it becomes that much more important to distinguish it from the more serious vision/life-threatening conditions like choroidal melanoma as well as from the other pigmented ocular fundus lesions associated with familial cancer syndromes like familial adenomatous polyposis.